5/12/2025
Last update
5/12/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.9
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Read More
9
Vitamin D3 mitigates autoimmune thyroiditis
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
Most Useful Reviews
9
Nails grew stronger
20 people found this helpful
Fantastic results! After two pregnancies, my nails were paper-thin and constantly breaking. Upon my friend’s suggestion, I tried these vitamins. At first, there was no visible change, but I persevered. After a month, my nails grew as never before—no breakage, and no bumps. I highly recommend this product!
Read More
7.5
Nail strength increased
38 people found this helpful
A drug that truly works! I’ve been on it for over six months, prescribed by my gynaecologist, cardiologist, and rheumatologist. I took one capsule daily and now two; I’m seeing noticeable results. My nails are stronger and grow well. I no longer experience tachycardia when changing my walking rhythm, and my digestive system has improved. Overall, I feel fantastic! I used to overpay significantly at the pharmacy, but now I only order from here and recommend it to everyone.
Read More
6
Neurologist-approved improvement
10 people found this helpful
I ordered this complex for my spouse as recommended by health professionals. After taking two capsules daily, improvements have been evident in his health assessments and overall condition. The tablets are somewhat large, but we’ve experienced no side effects. Overall, I am pleased with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.9
- All Researches
9.5
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Read More
9
Vitamin D3 mitigates autoimmune thyroiditis
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
Read More
9
We explored an intriguing instance of IgG4-related disease (IgG4-RD) manifesting as Mikulicz syndrome in an 85-year-old male patient. This condition usually involves significant systemic symptoms, yet our patient exhibited primarily local manifestations, specifically bilateral dacryoadenitis and orbital pseudotumor, without major organ complications.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Read More
9
Calcitriol improves immune regulation
We examined the effects of calcitriol, an active form of vitamin D3, on mesenchymal stem cells (MSCs) in a model of rheumatoid arthritis. To do this, we induced arthritis in BALB/c mice and divided them into three groups: those without treatment, those treated with untreated MSCs, and those treated with calcitriol-exposed MSCs.
After conducting our experiments, we found that MSCs treated with calcitriol demonstrated improved regulatory functions and inhibited inflammatory responses more effectively than untreated MSCs. Specifically, we observed differences in the behavior of immune cells, with calcitriol-treated cells showing reduced levels of certain inflammatory cytokines, like INF-γ and IL-17, while increasing beneficial cytokines such as IL-4, IL-10, and TGF-β.
These findings suggest that vitamin D3 may play an important role in moderating the immune response in autoimmune conditions like rheumatoid arthritis, potentially offering a pathway for more effective treatment options.
After conducting our experiments, we found that MSCs treated with calcitriol demonstrated improved regulatory functions and inhibited inflammatory responses more effectively than untreated MSCs. Specifically, we observed differences in the behavior of immune cells, with calcitriol-treated cells showing reduced levels of certain inflammatory cytokines, like INF-γ and IL-17, while increasing beneficial cytokines such as IL-4, IL-10, and TGF-β.
These findings suggest that vitamin D3 may play an important role in moderating the immune response in autoimmune conditions like rheumatoid arthritis, potentially offering a pathway for more effective treatment options.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Nails grew stronger
20 people found this helpful
Fantastic results! After two pregnancies, my nails were paper-thin and constantly breaking. Upon my friend’s suggestion, I tried these vitamins. At first, there was no visible change, but I persevered. After a month, my nails grew as never before—no breakage, and no bumps. I highly recommend this product!
Read More
7.5
Nail strength increased
38 people found this helpful
A drug that truly works! I’ve been on it for over six months, prescribed by my gynaecologist, cardiologist, and rheumatologist. I took one capsule daily and now two; I’m seeing noticeable results. My nails are stronger and grow well. I no longer experience tachycardia when changing my walking rhythm, and my digestive system has improved. Overall, I feel fantastic! I used to overpay significantly at the pharmacy, but now I only order from here and recommend it to everyone.
Read More
6
Neurologist-approved improvement
10 people found this helpful
I ordered this complex for my spouse as recommended by health professionals. After taking two capsules daily, improvements have been evident in his health assessments and overall condition. The tablets are somewhat large, but we’ve experienced no side effects. Overall, I am pleased with the results.
Read More
7.5
Reduced hair loss
5 people found this helpful
This calcium product from Solgar is fantastic! After struggling with brittle nails and hair loss, I found this remedy online. After a year of searching, I am delighted. My nails improved, I experienced less hair fall, and I absolutely enjoy taking it. The price difference compared to online pharmacies has impressed me positively, leading me to order from here. I’ll keep buying it!
Read More
9
Stronger hair noted
3 people found this helpful
I ordered this on October 2 and received it by the 7th. I previously bought vitamins from my local pharmacy, which I liked. Since starting this, my hair has noticeably strengthened, and my nails are no longer brittle. I highly recommend it!
Read More
Frequently Asked Questions
7
Sleep improved significantly
11 people found this helpful
Works wonders! After a month of use, I noticed tremendous changes. I became calmer, sleep improved, and waking up felt rejuvenating. Previously, I struggled with sleep and lethargy. My nails and hair are stronger, with noticeable growth. Magnesium apparently impacts me positively. I advise a dosage of five tablets a day, and I’m thrilled with my health. I’ve even lost 2 kg!
7.5
Nail growth improvement
1 people found this helpful
Tat `yana Aleksandrovna. Good calcium; of course, there will be no immediate effect. However, after drinking it for three months, I clearly see results. My nails have begun to grow and are wonderfully strengthened. I will certainly order more.
9
Nails grew stronger
20 people found this helpful
Fantastic results! After two pregnancies, my nails were paper-thin and constantly breaking. Upon my friend’s suggestion, I tried these vitamins. At first, there was no visible change, but I persevered. After a month, my nails grew as never before—no breakage, and no bumps. I highly recommend this product!
7.5
Nail strength increased
38 people found this helpful
A drug that truly works! I’ve been on it for over six months, prescribed by my gynaecologist, cardiologist, and rheumatologist. I took one capsule daily and now two; I’m seeing noticeable results. My nails are stronger and grow well. I no longer experience tachycardia when changing my walking rhythm, and my digestive system has improved. Overall, I feel fantastic! I used to overpay significantly at the pharmacy, but now I only order from here and recommend it to everyone.
9
Stronger hair noted
3 people found this helpful
I ordered this on October 2 and received it by the 7th. I previously bought vitamins from my local pharmacy, which I liked. Since starting this, my hair has noticeably strengthened, and my nails are no longer brittle. I highly recommend it!
9
Vitamin D3 mitigates autoimmune thyroiditis
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
9
Calcitriol improves immune regulation
We examined the effects of calcitriol, an active form of vitamin D3, on mesenchymal stem cells (MSCs) in a model of rheumatoid arthritis. To do this, we induced arthritis in BALB/c mice and divided them into three groups: those without treatment, those treated with untreated MSCs, and those treated with calcitriol-exposed MSCs.
After conducting our experiments, we found that MSCs treated with calcitriol demonstrated improved regulatory functions and inhibited inflammatory responses more effectively than untreated MSCs. Specifically, we observed differences in the behavior of immune cells, with calcitriol-treated cells showing reduced levels of certain inflammatory cytokines, like INF-γ and IL-17, while increasing beneficial cytokines such as IL-4, IL-10, and TGF-β.
These findings suggest that vitamin D3 may play an important role in moderating the immune response in autoimmune conditions like rheumatoid arthritis, potentially offering a pathway for more effective treatment options.
After conducting our experiments, we found that MSCs treated with calcitriol demonstrated improved regulatory functions and inhibited inflammatory responses more effectively than untreated MSCs. Specifically, we observed differences in the behavior of immune cells, with calcitriol-treated cells showing reduced levels of certain inflammatory cytokines, like INF-γ and IL-17, while increasing beneficial cytokines such as IL-4, IL-10, and TGF-β.
These findings suggest that vitamin D3 may play an important role in moderating the immune response in autoimmune conditions like rheumatoid arthritis, potentially offering a pathway for more effective treatment options.
9
We observed a fascinating interplay between vitamin D3 and immune responses in patients with multiple sclerosis (MS), an autoimmune disorder that leads to significant neurological damage. Our focus was on a type of immune cell called tolerogenic dendritic cells (tolDCs), which help maintain a balance in the immune system. In our study, we used monocytes from both healthy donors and treatment-naive MS patients to assess how these cells behaved under different conditions.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
8
In our exploration of vitamin D3's role in autoimmune hepatitis (AIH), we conducted a thorough study using a large patient database to highlight how vitamin D deficiency affects those struggling with this condition.
We found that individuals with low levels of vitamin D, especially those below the threshold of 20 ng/mL, faced significantly worse health outcomes compared to their counterparts who had sufficient vitamin D levels. This included a staggering increase in the likelihood of all-cause mortality, hospitalizations, and even the need for liver transplants.
While the study set out to uncover the potential benefits of vitamin D3 treatment, it lacked the necessary details to isolate its direct effects. Despite confirming that vitamin D deficiency is linked to serious complications in AIH, we were unable to draw firm conclusions regarding how vitamin D3 treatment might specifically improve patient outcomes.
Overall, our findings signal a compelling call for further research into the benefits of vitamin D3 supplementation for individuals battling autoimmune diseases like AIH, paving the way for possibly critical health interventions.
We found that individuals with low levels of vitamin D, especially those below the threshold of 20 ng/mL, faced significantly worse health outcomes compared to their counterparts who had sufficient vitamin D levels. This included a staggering increase in the likelihood of all-cause mortality, hospitalizations, and even the need for liver transplants.
While the study set out to uncover the potential benefits of vitamin D3 treatment, it lacked the necessary details to isolate its direct effects. Despite confirming that vitamin D deficiency is linked to serious complications in AIH, we were unable to draw firm conclusions regarding how vitamin D3 treatment might specifically improve patient outcomes.
Overall, our findings signal a compelling call for further research into the benefits of vitamin D3 supplementation for individuals battling autoimmune diseases like AIH, paving the way for possibly critical health interventions.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. 10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. 10.3389/fimmu.2025.1528707
- Mendoza-Vargas LÁ, Sevilla-Fuentes S, Bautista-Becerril B, Berthaúd-González B, Falfán-Valencia R, et al. IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report. J Clin Med. 2025;14. 10.3390/jcm14030958
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. 10.1111/apt.18438
- Dai J, Song J, Chen X, Ding F, Ding Y, et al. 1,25(OH)D-treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imbalance. Immunopharmacol Immunotoxicol. 2025;47:59. 10.1080/08923973.2024.2435314
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. 10.2478/aite-2024-0023
- Yu ZQ, Du HX, Gao S, Liang CZ. Eriocalyxin B ameliorated experimental autoimmune prostatitis via modulation of macrophage polarization through gut microbiota-mediated vitamin D alteration. Phytomedicine. 2024;135:156191. 10.1016/j.phymed.2024.156191
- Fondelli F, Willemyns J, Domenech-Garcia R, Mansilla MJ, Godoy-Tena G, et al. Targeting aryl hydrocarbon receptor functionally restores tolerogenic dendritic cells derived from patients with multiple sclerosis. J Clin Invest. 2024;134. 10.1172/JCI178949
- Grove-Laugesen D, Ebbehoj E, Watt T, Hansen KW, Rejnmark L. Changes in bone density and microarchitecture following treatment of Graves' disease and the effects of vitamin D supplementation. A randomized clinical trial. Osteoporos Int. 2024;35:2153. 10.1007/s00198-024-07241-y
- Zhang Q, He X, Chen W, Jiu J, Gao C, et al. Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis. Immunol Lett. 2024;269:106890. 10.1016/j.imlet.2024.106890
- Rodi M, de Lastic AL, Panagoulias I, Aggeletopoulou I, Kelaidonis K, et al. Myelin Oligodendrocyte Glycoprotein (MOG)35-55 Mannan Conjugate Induces Human T-Cell Tolerance and Can Be Used as a Personalized Therapy for Multiple Sclerosis. Int J Mol Sci. 2024;25. 10.3390/ijms25116092
- Maghbooli Z, Shirvani A, Moghadasi AN, Varzandi T, Hamtaei Ghashti S, et al. Investigating the effects of 25-hydroxyvitamin D3 on clinical outcomes in multiple sclerosis patients: A randomized, double-blind clinical trial- a pilot study. Mult Scler Relat Disord. 2024;87:105673. 10.1016/j.msard.2024.105673
- Fasihi M, Samimi-Badabi M, Robat-Jazi B, Bitarafan S, Moghadasi AN, et al. Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients. Antiinflamm Antiallergy Agents Med Chem. 2024;23:138. 10.2174/0118715230293847240314073359
- Durá-Travé T, Gallinas-Victoriano F. Autoimmune Thyroiditis and Vitamin D. Int J Mol Sci. 2024;25. 10.3390/ijms25063154
- Qu F, Zhang M, Weinstock-Guttman B, Zivadinov R, Qu J, et al. An ultra-sensitive and high-throughput trapping-micro-LC-MS method for quantification of circulating vitamin D metabolites and application in multiple sclerosis patients. Sci Rep. 2024;14:5545. 10.1038/s41598-024-55939-0
- Ji P, Qiu S, Huang J, Wang L, Wang Y, et al. Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. Adv Mater. 2025;37:e2415543. 10.1002/adma.202415543
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. 10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. 10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. 10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. 10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. 10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. 10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
